聚-L-乳酸微球延缓大鼠皮肤表皮干细胞的衰老

董云先1, 2, +，张有良2, +，于昊2, +，周玲聪2，张雅安2，汪海滨2, *，胡志成3, *罗盛康2, *

可注射皮肤填充剂为皮肤抗衰老和面部年轻化提供了更为多样的选择。聚左旋乳酸（PLLA）微球因其可降解性和持久性，越来越受到青睐，成为常用的填充材料。

Poly-l-lactic acid microspheres delay aging of epidermal stem cells in rat skin

Yunxian Dong1,2† , Youliang Zhang2† , Hao Yu2† , Lingcong Zhou2 , Yaan Zhang2 , Haibin Wang2 *, Zhicheng Hu3 * and Shengkang Luo2 *

Objective: Injectable skin fillers offer a wider range of options for cutaneous antiaging and facial rejuvenation. PLLA microspheres are increasingly favored as degradable and long-lasting fillers. The present study focused solely on the effect of PLL

由H4K12乳酰化和HDAC3驱动的反馈环在巨噬细胞中通过TGF-β信号通路调控乳酸诱导的成纤维细胞胶原合成

邹颖1,2，曹米布2，太美灵 3，周浩贤4，陶丽1，伍姝1， 杨凯业3，张有良2，葛远龙1,✉，王昊5,✉，罗盛康1,2,✉，鞠振宇1,2,✉

成纤维细胞胶原减少是皮肤老化的主要原因之一。乳酸可以通过调控基因转录，通过赖氨酸乳酰化参与胶原合成。然而，乳酸影响胶原合成的具体机制尚需进一步研究。

A Feedback Loop Driven by H4K12 Lactylation and HDAC3 in Macrophages Regulates Lactate-Induced Colla

Ying Zou, Mibu Cao, Meiling Tai, Haoxian Zhou, Li Tao, Shu Wu, Kaiye Yang, Youliang Zhang, Yuanlong Ge,* Hao Wang,* Shengkang Luo,* and Zhenyu Ju*

The decrease in fibroblast collagen is a primary contributor to skin aging.Lactate can participate in collagen synthesis through lysine lactylation by regulating gene transcription.